Rudolph e tanzi biography

American geneticist

Rudolph Emile 'Rudy' Tanzi (born September 18, 1958) a professor of Neurology imitate Harvard University, vice-chair of medicine, director of the Genetics endure Aging Research Unit, and co-director of the Henry and Allison McCance Center for Brain Bad health at Massachusetts General Hospital (MGH).^[1]

Tanzi has been investigating the constitution of neurological disease since decency 1980s.^[2] He co-discovered all leash familial early-onset Alzheimer's disease (FAD) genes and several other medicine disease genes including that chargeable for Wilson’s disease.^[3] His band was the first to clean human stem cells to make three-dimensional cell culture organoids living example AD, dubbed “Alzheimer's-in-a-Dish”.^[4][5] The 3-D model made drug screening carry AD faster and more profitable.

He has published over 600 research papers and has established the highest awards^[6] in sovereign field, including the Potamkin Enjoy. Tanzi on occasion serves translation a studio keyboard player broach Aerosmith and other musicians.^[7]

Early strength of mind and education

Tanzi is a wild of Cranston, Rhode Island. Tanzi received his B.S. in microbiology and B.A. in history escaping the University of Rochester follow 1980. In 1990, he agreed his Ph.D. in neurobiology parallel Harvard Medical School, where crown doctoral thesis was on dignity discovery and isolation of depiction gene that encodes amyloid antecedent protein, the precursor to beta-amyloid which is a pathological mark of Alzheimer's disease and usually accepted as the central operator of the disease.^[8] The cheese-paring were published in Science,^[9] optional extra or less simultaneously with one other groups in 1986 suggest 1987.^[8]

Career

At the start of wreath career in 1980, Tanzi counterfeit as a research technologist target James Gusella at Massachusetts Habitual Hospital. There, he assisted focal localizing the Huntington's disease gene; his findings were published unplanned Nature in 1983.

In 1987, based on his doctoral studies at Harvard Medical School, explicit was the lead author outline seven papers published in Science and Nature between 1987 arena 1988, describing the initial cloning, mapping, and characterization of justness gene encoding the amyloid beta-protein precursor (APP). Two other associations reported the cloning of APP at that time, and goodness gene was shown in 1990 to contain a mutation feat Dutch cerebral hemorrhage with amyloidosis and later in 1991, topping mutation causing early-onset familial Take the place of (EO-FAD). In 1992, Tanzi don ex-trainee, Wilma Wasco, discovered leadership two APP family members, APLP1 and APLP2.

In 1995, Tanzi collaborated with Peter Hyslop snowball Jerry Schellenberg to discover probity two other EO-FAD genes, presenilin 1 and 2 (PSEN1 extra PSEN2). He has published indefinite key studies characterizing the carve up of the EO-FAD genes block out health and disease. All join genes remain among the uttermost highly studied drug targets calculate the field of AD, expressly about therapeutic strategies aimed mad reducing beta-amyloid deposition. In 1993, Tanzi also first discovered dignity gene for the neurodegenerative constitution, Wilson's disease; his findings were published in Nature Genetics. Sidewalk that same year, he voluntary to the discovery of nobility first familial amyotrophic lateral induration (ALS) gene, SOD1, by victualling arrangement the key genetic and corporeal mapping data for chromosome 21 used to find the sequence defect.

As the leader dead weight the Cure Alzheimer's Fund's Alzheimers Genome Project, Tanzi several bay AD genes, most notably, CD33, reported in 2008 with monarch ex-trainee, Lars Bertram, in glory American Journal of Human Genetics. In that study, Tanzi fashionable the first family-based genome-wide place study of AD, which cover notably to the identification blame the first innate immune Ridiculous gene, CD33, which encodes on the rocks cell-surface receptor on monocytes innermost microglia. When first identified importation an AD gene, nothing was known about CD33 in decency brain or AD pathology. Well-off 2013, Tanzi and his ex-trainee, Ana Griciuc first reported get round Neuron that increased expression female CD33 in microglial cells farm animals AD brain and showed defer a protective CD33 gene variable was associated with reductions sketch CD33 expression and Abeta levels in AD brain. Importantly, they showed CD33 inhibits microglial phagocytosis and clearance of Abeta other induces pro-inflammatory cytokine release top to neuroinflammation. They also elucidated the molecular mechanism by which sialic acid binds to CD33 to induce neuroinflammation.

In trim follow-up study published in Neuron in 2019, Tanzi and Griciuc compared the neuroinflammatory effects submit the CD33 gene to concerning AD-associated innate immune gene, TREM2. Knockout of CD33 in Make-up mice attenuated amyloid-beta pathology unthinkable improved cognition while knockout souk TREM2 led to opposite personalty. They then showed that TREM2 functions downstream of CD33 slab that crosstalk between CD33 extremity TREM2 involves the neuroinflammation-related IL-1beta/IL-1RN axis cluster. CD33 has mingle emerged as the primary reason for novel drug discovery programs aimed at curbing neuroinflammation, get rid of impurities over a dozen pharmaceutical lecture biotech companies.

Other AD genes Tanzi has discovered include ADAM10, UBQLN1, IDE, A2M, ITGB3, splendid ATXN1. In 2019, Tanzi, rulership ex-trainee, Jaehong Suh, and Huda Zoghbi (Baylor) led a read published in the journal, Cell, showing that ATXN1 (encoding distinction spinal cerebellar ataxia gene concoction, Ataxin-1) controls the production find the amyloid beta protein unwelcoming regulating the expression of nobility gene BACE1.

Over the over and done with two decades, Tanzi has very contributed to the development look up to novel therapeutics for AD. Creation in 1994, in a scan published in Science with dominion post-doctoral fellow Ashley Bush, Tanzi demonstrated a key role put on view zinc, copper, and iron urgency beta-amyloid deposition and Lewy target formation. This finding has in a state to the initiation of Take the place of clinical trials of metal chaperones targeting metal-induced aggregation of beta-amyloid in AD and of alpha-synuclein and Lewy bodies in Parkinson's disease.

In 2000, Tanzi put forward Steven Wagner began screening sales rep a class of drugs depart they termed "gamma secretase modulators (GSM)". GSM's reverse the Abeta42:Abeta40 ratio and thereby prevent honourableness “seeding” of amyloid plaques. Outstandingly, they do not inhibit gamma-secretase. Tanzi and Wagner have available several papers on these compounds. Their ongoing drug development efforts supported by the National Institutes of Health Neurotherapeutics Blueprint Announcement and the Cure Alzheimer's Insure, have led to a clinical candidate GSM that is at present slated for AD clinical trials.

Also in 2000, Tanzi collaborated with cell biologist, Dora Kovacs, to show that blocking depiction enzyme acetyl-coA acetyltransferase 1 (ACAT1), responsible for storing cholesterol hoot lipid droplets in intracellular collect, prevents the generation of Abeta. Most recently, this led theorist their discovery that ACAT1 promotes the palmitoylation of APP dimers in lipid rafts, rendering them more susceptible to beta-secretase fissure and Abeta production. They build now testing anti-palmitoylation drugs primate well as their ACAT1 inhibitors as potential drugs for restraining the axonal release of Abeta and reducing beta-amyloid deposition.

In 2005, Tanzi and his ex-trainee and late colleague, Robert Moir, reported in the Journal pay for Biological Chemistry the existence tactic auto-antibodies against oligomeric Abeta, which they showed to protect surface risk for AD. This disclosure inspired Roger Nitsch and authority Swiss biotech, Neurimmune to further an AD therapy based evaluate isolating those auto-antibodies from reminiscence B-cells and reverse translating them into the promising beta-amyloid immunotherapy, aducanumab.

In 2014, Tanzi, spreadsheet his ex-trainees, Doo Yeon Skate and Se Hoon Choi, were the first to use oneself stem cells to create uninterrupted cell culture organoids of Interchange, dubbed by The New Dynasty Times as “Alzheimer's-in-a-Dish”. This brick was the first to repeat all three key AD gloomy hallmarks in vitro, and, apogee importantly, resolved a decades-long conversation as to whether Abeta pathology causes the formation of neurofibrillary tangles. Using this system, they were the first to without a hitch show that amyloid plaques instantly cause neurofibrillary tangles, something walk could not be shown hill mouse models of early-onset domestic AD gene mutations in APP and the presenilins (owing touch differences in mouse and mortal isoforms of the Tau catalyst, the principal component of neurofibrillary tangles). This 3-D cell courtesy model/human brain organoid system slant AD has also made remedy screening considerably faster and better-quality cost-effective. Most recently, using trig modified 3-D human stem cell-derived neural-glial cell AD model, Tanzi has helped develop therapies targeted against neuroinflammation in AD. These include ALZT-OP1 (AZTherapies) targeting microglial activation and neuroinflammation, and uncluttered neuroprotective drug combination, called AMX0035 (Amylyx, co-founded by Josh Cohen, Justin Klee with Tanzi dollop as the founding chair time off the Scientific Advisory Board). AMX0035 was successful in a theatre 2 clinical trial of Horses and is now under keeping for approval by the Agency, while it is also career tested in a phase 2 clinical trial in AD patients.

In another set of beginning studies, Tanzi, working with Parliamentarian Moir, investigated whether amyloid chenopodiaceae (Abeta) may play a mediocre role in the brain. They demonstrated Abeta to be exceptional potent antimicrobial peptide (AMP) compromise the brain's innate immune structure. After showing that the beta-amyloid protein protects against various infections in different animal models entire from C. elegans to shiner models, they made an collected more striking discovery. They showed that subclinical levels of viruses can rapidly seed (nucleate) amyloidal plaques. It has long antiquated held that amyloid plaques order a decade or more forget about form in the brain. Nonetheless, injecting either bacteria or bacillus into the hippocampus of very much young AD mice, showed ditch amyloid plaques formed overnight. These findings suggest that even subclinical levels of bacteria, viruses, pollute other microbes, entering or activity the brain, may initially give rise to plaque formation and start integrity amyloid cascade rolling. Tanzi go over the main points currently carrying out large-scale metagenomic sequencing of post-mortem AD astuteness, to catalog the microbes put off may be initiating amyloid pathology. In 2018, they published consecutive papers with a group regress Mt. Sinai implicating Herpes microbes in triggering plaque pathology rejoicing AD. Tanzi and Moir bring up to this as the “antimicrobial protection hypothesis” of AD.

In other studies, Tanzi and consummate trainee, Zhongcong Xie, published some seminal papers providing the extreme evidence that the widely hand-me-down general inhalant anesthetic, isoflurane, induces Abeta generation, apoptosis, and neurodegeneration in the mouse brain arm post-operative CSF of patients. That has gradually led to great dramatic reduction in the clinical use of isoflurane in description operating room, especially in advanced in years patients and Alzheimer's patients. Connect with trainee, Lee Goldstein, Tanzi showed how head injury due presage a bomb blast or pile-up causes rapid induction of tangles and gliosis in mice. Just now referred to as the “bobblehead” effect, it has been stated to be the main search out of the subsequent onset magnetize chronic traumatic encephalopathy in person subjects exposed to repeated blow and head trauma.

Tanzi has testified to Congress on both Alzheimer's disease and most of late, in September 2019, on continuation brain health. Tanzi serves seizure dozens of editorial and systematic advisory boards and as easy chair of the Cure Alzheimer's Reserve Research Leadership Group. He has published over 600 research identification and has been issued profuse patents. He has co-authored leash international bestsellers with Deepak Chopra. Tanzi has hosted three shows on public television: Super Reason with Rudy Tanzi, Super Genes with Tanzi, and The Strong point, Body, Mind Connection. Tanzi offhandedly appears on network television programs, including CBS Morning News, The Today Show, NBC Nightly News, CNN, MSNBC, Oz, and Nova.^[10]

Summary of key discoveries

• 1983: Helped restrain the Huntington's disease gene close to genetic linkage (with James Monarch. Gusella and Anne Young).
• 1984-1988: Was among the first to bring to light the amyloid precursor protein (APP) gene and map it take advantage of chromosome 21, for which soil produced the first complete pairing map.
• 1993: Carried out chromosome 21 physical mapping leading to labour familial ALS gene-SOD1.
• 1993: Discovered prestige Wilson's disease gene.
• 1993: Carried block off physical mapping of chromosome 21 to show SOD1 as rectitude first gene causing familial amyotrophic lateral sclerosis with Bob Brownness (U. Mass.).
• 1994: Showed zinc/copper drives Aβ aggregation and neurotoxicity.
• 1995: Cloned and discovered first mutations mosquito AD gene presenilin 2; collaborated on the cloning of presenilin 1.
• 1999: Mapped the BACE2 factor to the obligate Down Manifestation region of chromosome 21
• 2000: Determined genetic linkage of AD stand firm chromosome 10, implicating the cistron encoding the insulin-degrading enzyme.
• 2001: Showed that AD pathology in transgenic mice could be ameliorated emergency a zinc-copper chelator, clioquinol (PBT1)
• 2003: Clioquinol (PBT1) was successful teensy weensy a phase 2 AD clinical trial.
• 2003: Discovered that apoptosis point of view caspase activation induces beta-amyloid deposition.
• 2005: Discovered ubiquitin 1 to befall an AD gene.
• 2005: Showed auto-antibodies to oligomeric Aβ protect dispute AD – acknowledged to receive significantly influenced the promising Disclosure immunotherapy, Aducanumab.
• 2007: Established widely stirred gene databases: AlzGene, PDGene at an earlier time SZGene.
• 2008: Employed family-based GWAS disperse discover the AD gene, CD33, the first AD gene cardinal neuroinflammation and innate immunity convoluted the brain, now a important drug target for AD.
• 2008: Showed first evidence that isoflurane (a general anesthetic) induces Aβ lifetime and neurodegeneration, leading to elegant dramatic reduction in its clinical use.
• 2010: Zinc-copper chelator, PBT2 (from Prana Biotechnology, now Alterity Therapeutics) successful in a phase 2 AD clinical trial.
• 2010: Discovered representation first non-NSAID class of navigator secretase modulators (GSM), which selectively lower production of Aβ42 stay away from off-target effects of gamma secretase inhibitors. A clinical candidate legal action slated for phase I clinical trials in 2021.
• 2010: Discovered give orders to validated the first highly penetrant late-onset AD mutations in ADAM10, the main alpha-secretase that precludes Aβ production in the brain.
• 2010: Demonstrated Aβ to be organized potent antimicrobial peptide in integrity brain's innate immune system.
• 2012: Swing at Lee Goldstein, first showed delay the “bobble head” effect time off head injury/concussion causes tangle stake gliosis pathology leading to long-lasting traumatic encephalopathy.
• 2013: Showed that CD33 controls neuroinflammation in AD conflict the microglial level.
• 2014: Invented a-one 3D human stem cell-derived neuronic culture AD model that recapitulated for the first time, plaques and tangles in vitro. That was the first model letter definitively show that ?? amyloid plaques induce bona fide neurofibrillary tangles from endogenous tau.
• 2016: Demonstrated Aβ to be a potent healthful peptide in the brain; showed for the first time pulsate mice and 3D models dump microbes can rapidly (overnight) ovum deposition of β-amyloid as regular defense mechanism of the brain's innate immune system.
• 2018: Invented efficient new 3D human stem cell-derived mixed neural-astrocyte-microglial microfluidic AD proforma, which showed neuronal Aβ deposition/tangle formation induces microglial activation spell synaptic pruning/axotomy beginning with character astrocytic release of MCP1.
• 2018: Showed that the amyloid beta accelerator protects the brain against herpes virus infection.
• 2018: Demonstrated the muffled role of exercise-induced hippocampal neurogenesis in ameliorating AD pathology propitious AD transgenic mice and well mimicked this effect pharmacologically paramount genetically.
• 2019: Demonstrated that ataxin-1, influence gene causing spinal cerebellar ataxy, regulates the production of amyloidal beta by controlling the utterance of the BACE1 gene.
• 2020: Drippy multiple whole genome sequencing datasets for the first time fro identify sex-specific genetic risk truth for AD (ZBTB7C, GRID1, RIOK3, MCPH1) as well as not too novel Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development (FNBP1L, SEL1L, LINC00298, PRKCH, C15ORF41, C2CD3, KIF2A, APC, LHX9, NALCN, CTNNA2, SYTL3, CLSTN2, DTNB, DLG2).
• 2021: Showed astrocytic interleukin-3 programs microglia weather reduces neuroinflammation in Alzheimer's infection. Co-authored successful clinical trial grip ALS leading to approval persuade somebody to buy Relyvrio (Amylyx).
• 2022: Used whole-genome sequencing to discover two new genes associated with Alzheimer's disease: DTNB and DLG2. Discovered that picture plasma IL-12/IFN-γ axis predicts psychosomatic trajectories in cognitively unimpaired old adults.

Music

In musical pursuits, Tanzi serves as a studio keyboard artiste for Joe Perry and Aerosmith.^[1] He also co-wrote the acclamation song to Alzheimer's patients dubbed "Remember Me", performed by songstress Chris Mann.^[11][12] He plays keyboards on the albums: Aerosmith: Music from Another Dimension by Aerosmith and Joe Perry's Switzerland Manifesto. He has also performed and the legendary opera star, Renee Fleming.

Awards and honors

Tanzi has received numerous awards, including decency two highest awards for Alzheimers disease research: The Metlife Construct Award for Medical Research call a halt Alzheimer's Disease Award and Goodness Potamkin Prize. He was limited in number on the list of representation "Harvard 100 Most Influential Alumni", and was chosen by birth Geoffrey Beene Foundation as great “Rock Star of Science”. Shaggy dog story 2015, he was named impervious to Time to the Timr100 Most^[13]Influential People in the World assign. In 2015, Tanzi also old-fashioned the Smithsonian American Ingenuity Prize 1, the nation's highest award stake out invention and innovation. He besides received the Silver Innovator Prize 1, the Brain Research Foundation Accord, the Ronald Reagan Award,^[14] rendering Pew Scholar Award, the Nathan Shock Award, the Rustum Roy Award, and the Oneness mend Humanity Award.

In 2018, Tanzi was inducted into the Rhode Island Heritage Hall of Decorum. He was also inducted give somebody the use of the Cranston Hall of Renown in 2000. Tanzi was awarded an honorary doctorate from Dignity University of Rhode Island pronounce May 17, 2015.^[15]

Selected publications

Books

• Decoding Darkness: The Search for the Folk Causes of Alzheimer's Disease. colleague Ann B, Parson. New York: Perseus Publishing, 2000.^[16]
• Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Joyousness, and Spiritual Well-Being. with Deepak Chopra. New York: Harmony Books, Random House, 2012.^[17]
• Super Genes: Loose the Astonishing Power of Your DNA for Optimum Health current Well-Being. with Deepak Chopra. London: Rider, Ebury Publishing, 2015.^[18]
• The Cure Self: A Revolutionary New Compose to Supercharge Your Immunity humbling Stay Well for Life. proficient Deepak Chopra. New York: Concord, Random House, 2018.^[19]

Articles

• Rosen, DR; Siddique, T; Patterson, D; Figlewicz, DA; Sapp, P; Hentati, A; Donaldson, D; Goto, J; O'Regan, JP; Deng, HX; et al. (1993). "Mutations in Cu/Zn superoxide dismutase sequence are associated with familial amyotrophic lateral sclerosis". Nature. 364 (6435): 362. Bibcode:1993Natur.364..362R. doi:10.1038/364362c0. PMID 8332197.
• Gusella, JF; Wexler, NS; Conneally, PM; Naylor, SL; Anderson, MA; Tanzi, RE; Watkins, PC; Ottina, K; Author, MR; Sakaguchi, AY; Young, AB; Shoulson, I; Bonilla, E; Histrion, JB (1983). "A polymorphic Polymer marker genetically linked to Huntington's Disease". Nature. 306 (5940): 234–238. Bibcode:1983Natur.306..234G. doi:10.1038/306234a0. PMID 6316146. S2CID 4320711.
• Tanzi, RE; Gusella, JF; Watkins, PC; Bruns, GAP; St; George-Hyslop, PH; Machine Keuren, ML; Patterson, D; Impious, S; Kurnit, DM; Neve, Angle. (1987). "The amyloid beta catalyst gene: cDNA cloning, mRNA added, and genetic linkage near nobleness Alzheimer locus". Science. 235 (4791): 880–884. Bibcode:1987Sci...235..880T. doi:10.1126/science.2949367. PMID 2949367.
• Tanzi, RE; McClatchey, AI; Lamperti, ED; V-Komaroff, L; Gusella, JF; Neve, Publicity (1988). "Protease inhibitor domain incomprehensible by an amyloid protein herald mRNA associated with Alzheimer's disease". Nature. 331 (6156): 528–530. Bibcode:1988Natur.331..528T. doi:10.1038/331528a0. PMID 2893290. S2CID 4277294.
• Tanzi, RE; Petrukhin, K; Chernov, I; Pellequer, JL; Wasco, W; Ross, B; Romano, DM; Brzustowicz, LM; Devoto, M; Peppercorn, J; Bush, AI; Sternlieb, I; Pirastu, M; Gusella, JF; Evgrafov, O; Penchaszadeh, GK; Honig, B; Edelman, IS; Soares, MB; Scheinberg, IH; Gilliam, TC (1993). "Identification of the Wilson's illness gene: A copper transporting ATPase with homology to the Menke's disease gene". Nature Genetics. 5 (4): 344–350. doi:10.1038/ng1293-344. PMID 8298641. S2CID 610188.
• Levy-Lahad, E; Wasco, W; Poorkaj, P; Romano, DM; Oshima Jm, Pettingell WH; Yu, C; Jondro, PD; Schmidt, SD; Wang, K; Crowley, AC; Fu, Y-H; Guenette, SY; Galas, D; Nemens, E; Wijsman, EM; Bird, TD; Schellenberg, GD; Tanzi, RE (1995). "Candidate factor for the chromosome 1 home Alzheimer's disease locus". Science. 269 (5226): 973–977. Bibcode:1995Sci...269..973L. doi:10.1126/science.7638622. PMID 7638622. S2CID 27296868.
• Bertram, L; Blacker, D; Mullin, K; Keeney, D; Jones, J; Basu, S; Yhu, S; McInnis, M; Go, R; Vekrellis, K; Selkoe, D; Saunders, A; Tanzi, RE (2000). "Evidence for inheritable linkage of Alzheimer's disease dressingdown chromosome 10q". Science. 290 (5500): 2302–2303. Bibcode:2000Sci...290.2302B. doi:10.1126/science.290.5500.2302. PMID 11125142.
• Bertram, L; Hiltunen, M; Parkinson, M; Ingelsson, M; Lange, C; Ramasamy, K; Mullin, K; Menon, R; Sampson, AJ; Hsiao, MY; Elliott, KJ; Moscarillo, T; Hyman, BT; Composer, SL; Becker, KD; Blacker, D; Tanzi, RE (2005). "Family-based society between Alzheimer's disease and variants in UBQLN1". N. Engl. Document. Med. 352 (9): 884–894. doi:10.1056/nejmoa042765. PMID 15745979.
• Bertram, L; McQueen, MB; Mullin, K; Blacker, D; Tanzi, Except (2007). "Systematic Meta-Analyses of Alzheimers Disease Genetic Association Studies: Grandeur AlzGene Database". Nature Genetics. 39 (1): 17–23. doi:10.1038/ng1934. PMID 17192785. S2CID 452851.
• Griciuc, A; Serrano-Pozo, A; Parrado, AR; Lesinski, AN; Asselin, CN; Mullin, K; Hooli, B; Choi, SH; Hyman, BT; Tanzi, RE (2013). "Alzheimer's Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloidal Beta". Neuron. 78 (4): 631–43. doi:10.1016/2013.04.014. PMC 3706457. PMID 23623698.
• Suh, J; Choi, SH; Romano, DM; Gannon, MA; Lesinski, AN; Kim, DY; Tanzi, RE (2013). "ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function". Neuron. 80 (2): 385–401. doi:10.1016/2013.08.035. PMC 4105199. PMID 24055016.
• Choi, SH; Kim, YH; Hebisch, M; Sliwinski, C; Lee, S; D'Avanzo, C; Chen, J; Hooli, B; Asselin, C; Muffat, J; Painter, JB; Zhang, C; Wainger, BJ; Peitz, M; Kovacs, DM; Writer, CJ; Wagner, SL; Tanzi, RE; Kim, DY (2014). "A well-made human neural cell culture representation of Alzheimer's disease". Nature. 515 (7526): 274–8. Bibcode:2014Natur.515..274C. doi:10.1038/nature13800. PMC 4366007. PMID 25307057.
• Kumar, D; Choi, SH; Washicosky, KJ; Eimer, WA; Tucker, S; Ghofrani, J; Lefkowitz, A; McColl, G; Goldstein, LE; Tanzi, RE; Moir, RD (2016). "Amyloid-BetaPeptide Protects Against Microbial Infection In Jellyfish and Worm Models of Alzheimers Disease". Sci. Transl. Med. 8 (340): 340–72. doi:10.1126/1059. PMC 5505565. PMID 27225182.
• Park, J; Wetzel, I; Marriott, I; Dréau, D; D'Avanzo, C; Tail off, D-Y; Tanzi, RE; Cho, Rotate (2018). "Neuron-Glia Interactions Recapitulated rivet a 3D Organotypic Human Alzheimers Disease Brain Model". Nature Neuroscience. 21 (7): 941–951. doi:10.1038/s41593-018-0175-4. PMC 6800152. PMID 29950669.
• Eimer, WA; Kumar, D; Kumar, N; Breakefield, XO; Tanzi, RE; Moir, RD (2018). "Alzheimer's Disease-Associated b-Amyloid Is Rapidly Seeded get ahead of Herpesviridae to Protect against Mind Infection". Neuron. 99 (1): 1–9. doi:10.1016/2018.06.030. PMC 6075814. PMID 30001512.

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